Leukocytoclastic vasculitis (LCV), also known as hypersensitivity vasculitis and hypersensitivity angiitis, is a histopathologic term commonly used to denote a small-vessel vasculitis (see image shown below). Leukocytoclastic vasculitis has many causes, but no cause is identified in up to 50% of patients with this condition.
Histopathology of leukocytoclastic vasculitis. Leukocytoclastic vasculitis may be localized to the skin or may manifest in other organs. The internal organs affected most commonly include the joints, the gastrointestinal tract, and the kidneys. The prognosis is good in the absence of internal involvement.
Leukocytoclastic vasculitis may be acute or chronic. Chronic disease that primarily involves the skin should be treated with nontoxic modalities whenever possible, avoiding the use of systemic corticosteroids and immunosuppressive agents.
For additional information on cutaneous manifestations of leukocytoclastic vasculitis, see the eMedicine articleHypersensitivity Vasculitis (Leukocytoclastic Vasculitis) in the Dermatology volume.
Histopathology of leukocytoclastic vasculitis. Leukocytoclastic vasculitis may be localized to the skin or may manifest in other organs. The internal organs affected most commonly include the joints, the gastrointestinal tract, and the kidneys. The prognosis is good in the absence of internal involvement. Leukocytoclastic vasculitis may be acute or chronic. Chronic disease that primarily involves the skin should be treated with nontoxic modalities whenever possible, avoiding the use of systemic corticosteroids and immunosuppressive agents.
For additional information on cutaneous manifestations of leukocytoclastic vasculitis, see the eMedicine articleHypersensitivity Vasculitis (Leukocytoclastic Vasculitis) in the Dermatology volume.
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